Acrodermatitis continua can be resistant to treatment. It may be treated topically with glucocorticoids, calcipotriol, 5-fluorouracil or tacrolimus. Systemic treatments include oral retinoids, cyclosporine, methotrexate, and PUVA photochemotherapy. There are reports of improvement with NSAIDs. A combination of tacrolimus in the morning and calcipotriol at night is probably the best approach often showing very good improvement in 3 weeks. A previous patient of mine reported very good improvement with alternative medicine!
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