Helium Ion Microscopy of collagen (Photo credit: ZEISS Microscopy) Skin rejuvenation peptides are cosmetic dermatology’s answer to retinoids. Retinoids stimulate collagen production at the transcriptional level by directly interacting with nuclear receptors. The skin rejuvenation peptides trick the body into synthesizing more collagen. Collagen production and its ultimate destruction by […]

Peptide design for skin rejuvenation

Please read Argireline Part 1 and the full series here. Acetyl hexapeptide-3 has one major advantage. BoNT/A causes permanent destruction of SNAP-25 of the SNARE complex, triggering neuronal sprout formation and a steady recovery. Acetyl hexapeptide-3 acts like a competitive inhibitor of SNAP-25, so this recovery mechanism is not triggered. It is […]

The Embrace That SNAPS the SNARE – Argireline Part 2

Read the full series here. Matrixyl 3000 was a double-headed serpent (a mixture of Palmitoyl Oligopeptide & Palmitoyl Tetrapeptide-7). He had a weapon that others did not have: an anti-inflammatory sword. When Matrixyl’s son Tetrapeptide 21 was born, there was a voice from the heavens. “He who is born by immaculate […]

The peptide avengers – Part 4

Peptide bond formation. (Photo credit: Wikipedia) Read the full series here. KTTKS was the son of alpha-pro-collagen I, the most influential dermal fibrous protein. He was in the bad company of water because of his polar nature. Mr Pro-collagen I called KTTKS one day and told him a little secret. The […]

Hyaluronic Acid and the hidden beauty. Peptides Part 3

Read the full series here. Prologue: The dermis has fibrillar components called Collagen and Elastin embedded in an Extracellular matrix composed of Glicosamino glycans (GAG), hyaluronic acid being the most important (and popular). There are synthetic and degradation pathways for collagen like most other proteins in the body. The synthetic pathway […]

3 villains in the peptide story – Part 2

Axillary Pigmentation
The article below describes the use of topical niacinamide and topical desonide in axillary hyperpigmentation from the Dovepress journal: Clinical, Cosmetic and Investigational Dermatology. Axillary hyperpigmentation is considered a cosmetic condition in this part of the world, except in conditions like acanthosis nigricans or axillary freckling. I generally view studies on […]

Axillary hyperpigmentation