|War (Photo credit: beapen)|
Vascular endothelial growth factor (VEGF) is a signal protein that stimulates vasculogenesis and angiogenesis by binding to the VEGF receptors. VEGF receptors belong to the tyrosine kinase group and are implicated in the pathogenesis of melasma. In fact increased vascularity is emerging as the major pathogenic factor in melasma. The 578 Copper Bromide laser is supposed to improve melasma by reducing the expression of VEGF (Shall review separately later).
In short VEGF in PRP could potentially promote pigmentation. Its angiogenic potential is definitely useful in wound healing, but its anti-ageing property is dubious.