Gene expression study in Acne

Acne vulgaris ill artlibre jn
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Anti-inflammatory effects of a topical preparation containing nicotinamide: “Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study”

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This study published recently in dovepress journal, Clinical, Cosmetic and Investigational Dermatology highlights the importance of dysregulation of matrix metalloproteinase (MMP) and pro inflammatory cytokines like IL-6 in acne. The study shows that many MMPs and IL-6 are down-regulated when a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol is applied. But does it mean that these MMPs are up-regulated in active acne? Except for MMP1, all other MMPs found to be down-regulated are gelatinases and not collagenases. Zinc is an important cofactor for MMPs while doxycycline is an inhibitor. Both are found to be useful in the treatment of acne. So the MMP expression changes demonstrated in this study could just be an incidental finding!
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Bell Eapen

Techie Dermatologist, Information Systems Ph.D. candidate, Supporter of Open-Source Software, Machine Learning and AI geek,loves cricket, Canadian wine and beer, skeptical about the worth of Cosmetic Dermatology. [Resume]
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About Bell Eapen 244 Articles
Techie Dermatologist, Information Systems Ph.D. candidate, Supporter of Open-Source Software, Machine Learning and AI geek, loves cricket, Canadian wine and beer, skeptical about the worth of Cosmetic Dermatology. [Resume]

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