In analogy to the isomorphic nonresponse the term “isotopic nonresponse,”related to the isotopic response was, introduced in the original contribution by same authers. It define as the absence of an eruption at the site of another unrelated and already healed skin disease or the sparing of the sites of another unrelated and already healed skin disease. A variety of other related observations have also been reported. Happle et al. first introduced the term “Renbök phenomenon” or “Inverse Koebner Phenomenon” to describe the observation of normal hair growth in psoriatic plaques in patients with co-existing psoriasis and alopecia areata. Later,additional cases with alopecia areata sparing nevus flammeus and congenital melanocytic nevus were described. Mansur et al., suggested that a dermatosis sparing another co-existing unrelated previous skin disorder including Renbok phenomenon could be defined as a “reverse isotopic response’.
As most of these phenomenons have similar morphological features the diagnosis is often made on the basis of differences in the clinical presentation; however, some of the cutaneous reactions of similar phenomenon have been described using varied nomenclature, further adding to the confusion. In view of this, we defined each cutaneous reaction accordingly and classify the various types of these phenomenons under a broad universal term(s) but at the same time respecting the idea of differences might help better understanding of immuno – neuro -pathophysiology of these entities perhaps. In this article, 1 we provide a brief review of the literature of these various unique phenomenon – Koebner,Wolf isotopic, Renbok, Koebner nonreaction, Isotopic nonreaction and other related skin reaction as well as the proposed classification.
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- Kannangara, Ajith P; Yosipovitch, Gil; & Fleischer Jr., Alan B. (2014). Proposed classification for koebner, wolf isotopic, renbok, koebner nonreaction, isotopic nonreaction & other related phenomen. Dermatology Online Journal, 20(11). doj_24682. Retrieved from: http://escholarship.org/uc/item/96s656b4 ↩
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